Ultrastructural alterations within hyperplastic liver nodules induced by ethionine.
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منابع مشابه
The ultrastructure of ethionine-induced hyperplastic liver nodules was compared to the adjacent nonnodular liver in the same rat and also to hyperplastic liver nodules induced by 2-fluorenylacetamide. Several reproducible cytostructural
The ultrastructure of ethionine-induced hyperplastic liver nodules was compared to the adjacent nonnodular liver in the same rat and also to hyperplastic liver nodules induced by 2-fluorenylacetamide. Several reproducible cytostructural alterations were noted in ethionine-induced hyperplastic liver nodules of fasted animals but not in adjacent nonnodular liver. This set of alterations was quite...
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SUMMARY Different functional and structural properties of rat liver microsomes were studied during hepatocarcinogenesis induced by 0.25% m-ethionine. During the first to fourth months of ethionine feeding, great decreases of cytochrome P-450 content, reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation, and aminopyrine demethylase activity occurred. No changes in the...
متن کاملCellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism.
A dietary regimen is described whereby large hyperplastic nodules can be obtained in over half the rats fed either of the two hepatocarcinogens, ethionine or 2-fluorenylacetamide. The nodules are composed predominantly of hepatocytes which show morphologic and biochemical differences from the surrounding nonhyperplastic liver. The glycogen or its metabolic control are different in the nodule in...
متن کاملCellular Analysis of Liver Carcinogenesis: the Induction of Large Hyperplastic Nodules in the Liver with 2-Fluorenylacetamide or Ethionine and Some Aspects of Their Morphology and Glycogen Metabolism1
A dietary regimen is described whereby large hyperplastic nodules can be obtained in over half the rats fed either of the two hepatocarcinogens, ethionine or 2-fluorenylacetamide. The nodules are composed predominantly of hepatocytes which show morphologic and biochemical differences from the surrounding nonhyperplastic liver. The glycogen or its metabolic control are different in the nodule in...
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ورودعنوان ژورنال:
- Cancer research
دوره 31 2 شماره
صفحات -
تاریخ انتشار 1971